Saturday, 01 July 2023 03:10

Controversial 'vaginal seeding' shows promise in small trial, but questions remain

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"Vaginal seeding," a controversial practice of exposing babies born by cesarean section to their parent's vaginal fluids after birth, may benefit newborns' gut microbiomes, a new study suggests.

Babies born by C-section don't have the same gut microbes as those born vaginally, potentially because they're not exposed to their parent's vaginal microbiome during birth. Studies have shown that the gut microbiomes of cesarean-born newborns more closely resemble the communities of microbes that typically inhabit the skin, rather than the gut. This has raised questions about how birth methods affect babies' development, given evidence that the community of microbes in the intestines, or gut microbiota, shapes the brain and immune system in early life.

Studies have linked cesarean births to a higher risk of neurodevelopmental disorders,  early-life infections, allergies, inflammatory diseases and metabolic diseases, and some suspect that differences in gut microbiota may contribute to this risk.

The new study, published June 15 in the journal Cell Host & Microbe, suggests that vaginal microbiota transfer (VMT), also known as vaginal seeding, is likely a safe and effective method of restoring the gut microbiome in cesarean-born infants so that it resembles that of vaginally delivered babies. 

To establish the potential safety and benefit of vaginal seeding, researchers across multiple institutions in China conducted a clinical trial that included 68 pregnant women scheduled for C-sections. Around half of the women's babies were exposed to a gauze that contained the vaginal fluids of their mother, and the other half were exposed to a sterile saline gauze. 

The incidence of adverse events in the first 42 days after birth was similar in both groups of  babies, indicating that vaginal seeding is safe. The most common adverse events were mild skin disorders, including redness and blister-like sores; none of these events could be attributed to vaginal seeding.

The babies' gut microbiota were sampled at several points after birth, and an analysis showed that gut microbiota in the babies in the vaginal seeding group moved faster from "stunted" types to "mature" types, compared with the microbiota of the control group. 

For comparison, the team also studied the microbiomes of 33 vaginally born babies. The results showed that babies who had undergone vaginal seeding had gut microbiota that more closely resembled that of the vaginally delivered group.

The team also found that infant neurodevelopment at six months, as measured by scores on a common developmental screening questionnaire, was significantly higher for babies exposed to vaginal fluids compared with those exposed to saline, suggesting that vaginal seeding could improve neurodevelopment in cesarean-born babies. However, inferences about any potential long-term impact of vaginal seeding on neurodevelopment cannot be made since the study only measured out to six months. 

 

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